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Estrogen and testosterone therapy increases the risk of developing breast cancer

Estrogen and testosterone therapy increases the risk of developing breast cancer



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The role of androgens in the etiology of breast cancer is currently unknown. Epidemiological studies suggest that endogenous testosterone levels are associated with increased risk of breast cancer in menopausal women. Given the current trend of increasing use of androgen-containing hormone therapy, the team of researchers has decided to evaluate the relationship between estrogen and testosterone therapies and breast cancer.


The role of androgens in the etiology of breast cancer is currently unknown. Epidemiological studies suggest that endogenous testosterone levels are associated with increased risk of breast cancer in menopausal women. Given the current trend of increasing use of androgen-containing hormone therapy, the team of researchers has decided to evaluate the relationship between estrogen and testosterone therapies and breast cancer.
This prospective study (Nurses' Health Study) conducted between 1978-2002 evaluated the risk of developing breast cancer associated with the different types of hormonal therapies for menopausal women, containing therapeutic formulas and testosterone. During the 24 years of follow-up of the group of 1359323 women investigated, 4610 cases of invasive breast cancer were identified in menopausal women. Information on menopause status, hormonal therapy use and breast cancer diagnosis were updated every 2 years through questionnaires applied to women in the group.
In the naturally occurring menopause category, the risk of developing breast cancer was approximately 2.5 times higher in women using hormone therapy with estrogen and testosterone compared to those not using hormone therapy.
The analysis of the results showed that the risk of developing breast cancer associated with the current use of hormone therapy with estrogen and testosterone was significantly increased compared with hormone therapies using only estrogen and only slightly higher than hormone therapies using estrogen and progesterone. . Women using testosterone hormone therapy had a 17.2% increase in the risk of developing breast cancer with each year of therapy use.
In conclusion, women using hormone therapy with estrogen and testosterone had a significant increase in the risk of invasive breast cancer.